Assessment of the functional state and level of physical fitness of people with immunodeficiency virus with different levels of T-lymphocytes in the practice of a physical therapist
Purpose: to assess the functional state of patients with human immunodeficiency virus with different levels of T-lymphocytes for use in the practice of physical therapy.
Materials and methods. We examined 24 patients with human immunodeficiency virus at the stage of acquired immunodeficiency syndrome at the outpatient stage of treatment. The patients were divided into 2 groups. Group 1 included 11 patients with CD4+ T-lymphocyte levels <100 cells ml-1, and group 2 included 13 patients with CD4+ T-lymphocyte levels above 150 cells ml-1 (р<0.01). The clinical and anamnestic data, the main anthropometric parameters and physiological indices, the results of carpal dynamometry, the 6-minute walk test, characterizing the functional state of people living with the human immunodeficiency virus, were studied. The results of immunological, virological and biochemical parameters were also studied.
Results. Anthropometric indicators: Group 1 – body mass index 48.9±7.4 kg m2-1, waist to hip ratio ratio 0.92±0.17 cm, leg circumference 16.6±0.8 cm; Group 2 – body mass index 23.1±2.8 kg m2-1, waist to hip ratio ratio 1.14±0.11 cm, leg circumference 15.9±1.4 cm (р>0.05 ). Indicators of physiological indices: Reed - group 1 - 17.3±7.2%, group 2 - 18.3±11.8% (p>0.05); Hobbes - group I 70.9 ± 5.5%, group 2 - 93.6 ± 11.8% (p<0.05), Kerdo - group 1 was 26.6 ± 14.2%, group 2 - 10 .8 ± 14.7% (р<0.05). Index of functional changes group 2 - 2.44±0.2 points, group 2 - 2.59±0.3 points (p>0.05). Dynamometry indicators - group I - 17.5 ± 6.8 kg, group 2 - 28.1 ± 9.4 kg (р>0.05); strength index – group 1 35.3±-9.6%, group 2 40.5±10.4% (р>0.05); 6 min walk test in group 1 - 402.8±40.04 m, group 2 459.7±56.1 m (р<0.05). Indicators of biochemical studies were in reference values ??in patients of both groups.
Conclusions. There is a decrease in the functional state and the predominance of catabolic processes in people with human immunodeficiency virus with a significant deficiency of CD4+ T-lymphocytes.
1 de Souza A, da Silva Cunha de Medeiros, da Silva TAL, de Medeiros DC., de Medeiros JA., Dos Santos IK. et al. Effect of Training and Detraining in the Components of Physical Fitness in People Living With HIV/AIDS Front Physiol. 2021 Sep 22; 12:586-753. doi: 10.3389/fphys.2021.586753. eCollection 2021.
Gomes-Neto M, Saquetto MB, Alves IG, Martinez BP, Vieira JPB, Effects of Exercise Interventions on Aerobic Capacity and Health-Related Quality of Life in People Living With HIV/AIDS: Systematic Review and Network Meta-Analysis. Brites C.Phys Ther. 2021 Jul 1;101(7):pzab092. doi: 10.1093/physical therapyj/pzab092.
Tuñón-Suárez M, Reyes-Ponce A, Godoy-Órdenes R, Quezada N, Flores-Opazo M. Exercise Training to Decrease Ectopic Intermuscular Adipose Tissue in Individuals With Chronic Diseases: A Systematic Review and Meta-Analysis. Phys Ther. 2021 Oct 1;101(10):pzab162. doi: 10.1093/physical therapyj/pzab162. PMID: 34174085.
Marcinovs'ka V, Matiushkina K, Antonenko Zh. Informacijnij biuleten' «VIL-infekc2a v Ukraini» vol. 52, DU «Centr gromads'kogo zdorov’ia MOZ Ukraini» 2021 109 P.
Mayo NE, Brouillette MJ, Nadeau L, Dendukuri N, Harris M, Smaill F et al. Investigators from the Positive Brain Health Now Study. A longitudinal view of successful aging with HIV: role of resilience and environmental factors. Qual Life Res. 2021 Aug 30. doi: 10.1007/s11136-021-02970-7. Epub ahead of print. PMID: 34460077.
Chetty L, Cobbing S, Chetty V. Physical activity and exercise for older people living with HIV: a protocol for a scoping review. Syst Rev. 2020 Mar 20;9(1):60. doi: 10.1186/s13643-020-01327-4. PMID: 32197654; PMCID: PMC7085181.
Umbleja T, Brown TT, Overton ET, Ribaudo HJ, Schrack JA, Fitch KV et al. Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE. J Infect Dis. 2020 Jul 9;222(Suppl 1):52-62. doi: 10.1093/infdis/jiaa249. PMID: 32645163; PMCID: PMC7347078.
deBoer H, Andrews M, Cudd S, Leung E, Petrie A, Chan Carusone S, O'Brien KK. Where and how does physical therapy fit? Integrating physical therapy into interprofessional HIV care. Disabil Rehabil. 2019 Jul;41(15):1768-1777. doi: 10.1080/09638288.2018.1448469. Epub 2018 Mar 13. PMID: 29529881.
Ozemek C, Erlandson KM, Jankowski CM. Physical activity and exercise to improve cardiovascular health for adults living with HIV. Prog Cardiovasc Dis. 2020 Mar-Apr;63(2):178-183. doi: 10.1016/j.pcad.2020.01.005. Epub 2020 Jan 31. PMID: 32014512.
Saito, A., Karama, M. & Kamiya, Y. HIV infection, and overweight and hypertension: a cross-sectional study of HIV-infected adults in Western Kenya. Trop Med Health (2020) 48, 31. https://doi.org/10.1186/s41182-020-00215-w
Silva BF, Barletta F, Pedro RE, Batista ML Jr, Hernandes L, de Moraes SMF, Peres SB.Appl Concurrent training remodels the subcutaneous adipose tissue extracellular matrix of people living with HIV: a non-randomized clinical trial. Physiol Nutr Metab. 2021 Jul 22:1-11. doi: 10.1139/apnm-2021-0284. Online ahead of print.PMID: 34293264
Willig A, Wright L, Galvin TA. Practice Paper of the Academy of Nutrition and Dietetics: Nutrition Intervention and Human Immunodeficiency Virus Infection. J Acad Nutr Diet. 2018 Mar;118(3):486-498. doi: 10.1016/j.jand.2017.12.007.
Sáez-Cirión A, Sereti I. Immunometabolism and HIV-1 pathogenesis: food for thought. Nat Rev Immunol. 2021 Jan;21(1):5-19. doi: 10.1038/s41577-020-0381-7.
Shytaj IL, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, et al. Alterations of redox and iron metabolism accompany the development of HIV latency. EMBO J. 2020 May 4;39(9):e102209. doi: 10.15252/embj.2019102209.
Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, et al. Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection. Cell Metab. 2019 Mar 5;29(3):611-626.e5. doi: 10.1016/j.cmet.2018.11.015. Epub 2018 Dec 20. PMID: 30581119.
van Gurp PJ, Tack CJ, van der Valk M, Reiss P, Lenders JW, Sweep FC, Sauerwein HP. Sympathetic nervous system function in HIV-associated adipose redistribution syndrome. AIDS. 2006 Mar 21;20(5):773-5. doi: 10.1097/01.aids.0000216379.91936.84. PMID: 16514309.
Lopes KG, Farinatti P, Lopes GO, Paz GA, Bottino DA, Oliveira RB et al.. Muscle mass, strength, bone mineral density and vascular function in middle-aged people living with HIV vs. age-matched and older controls. Braz J Infect Dis. 2021 Nov-Dec;25(6):101654. doi: 10.1016/j.bjid.2021.101654. Epub 2021 Nov 24. PMID: 34826379.
Orton PM, Sokhela DG, Nokes KM, Perazzo JD, Webel AR. Factors related to functional exercise capacity amongst people with HIV in Durban, South Africa. Health SA. 2021 Apr 29;26:1532. doi: 10.4102/hsag.v26i0.1532. PMID: 34007474; PMCID: PMC8111642.
Kozin S, Cretu M, Kozina Z, Chernozub A, Ryepko O, Shepelenko T, Sobko I., Oleksiuk M. Application closed kinematic chain exercises with eccentric and strength exercises for the shoulder injuries prevention in student rock climbers: A randomized controlled trial. Acta of Bioengineering and Biomechanics, 2021, 23(2). https://doi.org/10.37190/ABB-01828-2021-01
Muszkieta R, Napierała M, Cieślicka M, Zukow W, Kozina Z, Iermakov S, et al. The professional attitudes of teachers of physical education. 2018. Journal of Physical Education and Sport. 2019;19:100-7.
Kozin SV, Safronov DV, Kozina ZL, Kniaz HO, Proskurnia O, Prontenko K, Lahno O, Goncharenko V, Kholodniy A, Comparative biomechanical characteristics of one-arm hang in climbing for beginners and qualified athletes, Acta Bioeng Biomech, 2020;22(1): 57-67, https://doi.org/10.37190/ABB-01440-2019-03.
Copyright (c) 2022 Health, sport, rehabilitation
This work is licensed under a Creative Commons Attribution 4.0 International License.